Evaluation of in-vitro antibacterial activity and anti-inflammatory activity for different extracts of Rauvolfia tetraphylla L. root bark
Asian Pacific Journal of Tropical Biomedicine
;
(12): 818-821, 2012.
Artículo
en Inglés
| WPRIM
| ID: wpr-303597
ABSTRACT
<p><b>OBJECTIVE</b>To assess the in-vitro antibacterial activity and anti-inflammatory activity of orally administered different extracts (Hydro-alcoholic, methanolic, ethyl acetate and hexane) of Rauvolfia tetraphylla (R. tetraphylla) root bark in Carrageenan induced acute inflammation in rats.</p><p><b>METHODS</b>In-vitro antibacterial activity was evaluated for extracts against four Gram positive and four Gram negative bacteria by using cylinder plate assay. Hydro-alcoholic extract (70% v/v ethanol) at 200, 400 and 800 mg/kg doses and methanolic, ethyl acetate and hexane extracts at doses 100, 200 and 400 mg/kg were tested for anti-inflammatory activity in Carrageenan induced rat paw oedema model and paw thickness was measured every one hour up to 6 hrs.</p><p><b>RESULTS</b>All extracts of R. tetraphylla root bark showed good zone of inhibition against tested bacterial strains. In Carrageenan induced inflammation model, hydro-alcoholic and methanolic extract of R. tetraphylla root bark at three different doses produced significant (P<0.001) reduction when compared to vehicle treated control group and hexane, ethyl acetate extracts.</p><p><b>CONCLUSIONS</b>In the present study extracts of R. tetraphylla root bark shows good in-vitro antibacterial activity and in-vivo anti-inflammatory activity in rats.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Rauwolfia
/
Bacterias
/
Extractos Vegetales
/
Carragenina
/
Pruebas de Sensibilidad Microbiana
/
Química
/
Raíces de Plantas
/
Corteza de la Planta
/
Modelos Animales de Enfermedad
Límite:
Animales
Idioma:
Inglés
Revista:
Asian Pacific Journal of Tropical Biomedicine
Año:
2012
Tipo del documento:
Artículo
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