Influence of pinacidil on the myocardial mitochondrial structure and the respiratory function in scalded rats / 中华烧伤杂志
Chinese Journal of Burns
;
(6): 170-172, 2005.
Artículo
en Chino
| WPRIM
| ID: wpr-303672
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the influence of pinacidil preconditioning on the protection of the structure and respiratory function of injured myocardial mitochondria in scalded rats.</p><p><b>METHODS</b>Seventy-five healthy Wistar rats, weighed 250 approximately 300 g, were randomly divided into three groups i.e. control (n = 9, with intraperitoneal injection of 50 microg/kg isotonic saline), scald (n = 33, with 30% TBSA full thickness scald) and pre-conditioning (n = 33, with same extent of scald injury after intraperitoneal injection of 50 microg/kg pinacidil) groups. Mitochondrial ultrastructure was observed by transmission electron microscope. The mitochondrial respiratory function, the MDA content and the superoxide anion level were determined with corresponding methods.</p><p><b>RESULTS</b>The degree of injury to rat myocardial mitochondria in pre-conditioning group was less intensive than that in scald group (P < 0.05 or 0.01). The respiratory control rate in pre-conditioning group was obviously higher than that in scald group (P < 0.05), and the contents of MDA and superoxide anion in pre-conditioning group were markedly lower than those in scald group (P < 0.05 or 0.01), as evidenced by their contents at 3 post scalding hours (0.60 +/- 0.09 micromol/g and 0.127 +/- 0.020) were obviously lower than those in scald group (0.83 +/- 0.07 micromol/g and 0.169 +/- 0.015) (P < 0.01).</p><p><b>CONCLUSION</b>Pinacidil preconditioning was beneficial in the protection of myocardial mitochondria in scalded rats, and it might be related to the pre-opening of potassium channel which was sensitive to mitochondrial ATP.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Quemaduras
/
Ratas Wistar
/
Superóxidos
/
Respiración de la Célula
/
Pinacidilo
/
Usos Terapéuticos
/
Modelos Animales de Enfermedad
/
Quimioterapia
/
Metabolismo
Límite:
Animales
Idioma:
Chino
Revista:
Chinese Journal of Burns
Año:
2005
Tipo del documento:
Artículo
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