Effect of Panax notoginseng saponins on human kidney fibroblast / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
; (12): 47-49, 2002.
Article
en Zh
| WPRIM
| ID: wpr-304251
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of Panax notoginseng saponins (PNS) on cell proliferation, type I collagen secretion and integrin beta 1 expression in human kidney fibroblast (KFB).</p><p><b>METHODS</b>KFB were cultured and stimulated by PNS in vitro. The cell proliferation, type I collagen secretion and integrin beta 1 expression in KFB were measured by methyl thiazolyl tetrazolium (MTT), enzyme-linked immunoabsorbent assay (ELISA) and flowcytometry respectively.</p><p><b>RESULTS</b>Within its optimal concentration range and effective time range, PNS could obviously inhibit the proliferation, type I collagen secretion and integrin beta 1 expression (all P < 0.05) in human KFB.</p><p><b>CONCLUSION</b>PNS would possibly be an effective drug for renal interstitial fibrosis prevention and treatment.</p>
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Patología
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Farmacología
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Saponinas
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Fibrosis
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Células Cultivadas
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Química
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Integrina beta1
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Biología Celular
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Colágeno Tipo I
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Fibroblastos
Límite:
Humans
Idioma:
Zh
Revista:
Chinese Journal of Integrated Traditional and Western Medicine
Año:
2002
Tipo del documento:
Article