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Progress in improvement of lentiviral vectors' transcriptional read-through / 生物工程学报
Chinese Journal of Biotechnology ; (12): 1541-1548, 2011.
Artículo en Chino | WPRIM | ID: wpr-304547
ABSTRACT
Four out of 10 patients of X-linked severe combined immunodeficiency (X-SCID) were finally developed leukemia after receiving the treatment of gene therapy delivered by gamma-retroviral vectors. This is due to the vector integrated to the proximity of lmo2 etc proto-oncogene promoters, leading to the activation of onco-gene expression, which raises the concern of the bio-safety of gene therapy vectors. Lentiviral vectors, especially self-inactivating lentiviral vectors, are considered to be much safer than gamma-retroviral vectors. However self-inactivating lentiviral vectors also have encountered with some unsafe factors and one of them is the problem of transcriptional "read-through" . During the past years, achievements have been made to reduce lentiviral vector transcriptional read-through, which are reviewed herein.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Transcripción Genética / Terapia Genética / Proteínas Proto-Oncogénicas / Regiones Promotoras Genéticas / Integración Viral / Lentivirus / Inactivación de Virus / Vectores Genéticos / Genética / Metabolismo Límite: Animales / Humanos Idioma: Chino Revista: Chinese Journal of Biotechnology Año: 2011 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Transcripción Genética / Terapia Genética / Proteínas Proto-Oncogénicas / Regiones Promotoras Genéticas / Integración Viral / Lentivirus / Inactivación de Virus / Vectores Genéticos / Genética / Metabolismo Límite: Animales / Humanos Idioma: Chino Revista: Chinese Journal of Biotechnology Año: 2011 Tipo del documento: Artículo