Electrophysiological effects of acehytisine hydrochloride in a porcine model of acute coronary occlusion / 中华心血管病杂志

ABSTRACT

<p><b>OBJECTIVE</b>To observe the electrophysiological effect of Acehytisine Hydrochloride (AHH) in Wu Zhi Shan (WZS) micropigs with experimental acute coronary occlusion.</p><p><b>METHODS</b>Adult WZS micropigs were randomized into group A coronary ligation with AHH infusion (n = 9); group B AHH infusion without coronary ligation (n = 9) and group C coronary ligation with saline (NS) infusion (n = 9). Surface ECGs and cardiac electrophysiological data including atrium, atrium-ventricle junction and ventricle electrograms were collected by programmed electrical stimulation at ischemic baseline and after AHH (or NS) infusion.</p><p><b>RESULTS</b>Compared to animals treated with AHH without ischemia, VARC-ERP was significantly increased while QT, QTc intervals, VRRP and VFRP were significantly reduced in ischemic animals treated with AHH. Compared to ischemic animals treated with saline, AHH prolongs the P-wave duration and PR interval, shortens QTc interval, prolongs ARP and AEP, also prolongs V-A reverse conduction time and VARC-ERP but shortens VFRP. No proarrhythmia effect was found in both AHH treated groups.</p><p><b>CONCLUSION</b>AHH resulted in significant electrophysiological effects on this porcine acute coronary ischemic model.</p>