Prior infected influenza virus could protect mice from challenge of lethal influenza virus / 中华实验和临床病毒学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To determine whether it could protect mice from challenge of lethal influenza virus which group prior infected A(H1N1) pdm09 and H9N2 virus respectively.</p><p><b>METHODS</b>150 BALB/c mice are divided into three groups. Mice are infected A(H1N1) pdm09 virus (pCA07) and poultry H9N2 virus (GZ333) respectively. Infected mice are challenged with 10 times of lethal dose virus (PR8) then compare the viral load, antibody and survival of the two group mice before and after challenged.</p><p><b>RESULTS</b>Both experimental group mice survived after challenge of lethal influenza virus and lung viral load are lower than that of the first infection. Antibodies derived from the infective virus and challenge virus.</p><p><b>CONCLUSION</b>Prior infected A(H1N1) pdm09 and H9N2 virus could protect mice from challenge of lethal influenza virus.</p>