Serological survys on anti-H1N1 IgG of blood donors in Dongguan / 中华实验和临床病毒学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To access the sustained immune effect in influenza A H1N1 vaccine vaccinated-blood donors as well as the level of anti-H1N1 IgG in unvaccinated-blood donors in order to provide reference for preventing and treating influenza A H1N1.</p><p><b>METHODS</b>Anti-H1N1 IgG was detected in 1166 vaccinated-blood donors as well as 1265 unvaccinated-blood donors by ELISA method in Dongguan from January 2010 to June 2010.</p><p><b>RESULTS</b>The mean positive rate and high-titer rate of anti-H1N1 IgG were 78.82% and 46.57% respectively, both of which were sustained at relatively high level after reaching their peak at vaccination time of 71-90 d. The mean positive rate of anti-H1N1 IgG in unvaccinated-blood donors was 26.01%. No difference was found in the positive rate of anti-H1N1 IgG among different gender or age groups (P > 0.05).</p><p><b>CONCLUSION</b>The influenza A H1N1 vaccine, with good sustained immune effect, plays an important role in preventing and treating influenza A H1N1. The positive rate of anti-H1N1 IgG in influenza A HIN1 vaccine unvaccinated-blood donors is low. Vaccination should be strengthened.</p>