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HBV genotypes distribution and YMDD spontaneous mutation in Qingdao population / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology ; (6): 250-252, 2012.
Artículo en Chino | WPRIM | ID: wpr-305068
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the distribution of hepatitis B virus (HBV) genotypes in Qingdao, and the relationship of HBV genotypes with the serum HBV-DNA levels and HBV YMDD spontaneous mutation of patients, then to discuss the clinical significance.</p><p><b>METHODS</b>Hepatitis B virus genotypes and YMDD spontaneous mutation of 144 patients were detected by real time PCR (Taqman probe), then the results were analyzed by statistical method.</p><p><b>RESULTS</b>Of the 144 patients, 130 (90.3%) were genotype C, 12 (8.3%) were genotype B, and 2 (1.4%) were neither genotype B nor genotype C; 33 (22.9%) were detected to have YMDD mutation, and 25 (75.5%) were YVDD positive, 3 (9.1%) were YIDD positive, 5 (15.2%) were YVDD and YIDD positive. There were no significant differences between clinical diagnosis, serum HBV-DNA levels, YMDD spontaneous mutation and HBV genotypes (P > 0.05).</p><p><b>CONCLUSION</b>Genotype C is the dominant position for HBV genotype in Qingdao. Untreated patients with chronic hepatitis B have YMDD spontaneous mutation. HBV genotypes have no association with YMDD spontaneous mutation and the development of diseases.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Proteínas Virales / Química / China / Virus de la Hepatitis B / Clasificación / ADN Polimerasa Dirigida por ADN / Genética / Genotipo / Metabolismo / Mutación Límite: Adulto / Anciano / Aged80 / Femenino / Humanos / Masculino País/Región como asunto: Asia Idioma: Chino Revista: Chinese Journal of Experimental and Clinical Virology Año: 2012 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Proteínas Virales / Química / China / Virus de la Hepatitis B / Clasificación / ADN Polimerasa Dirigida por ADN / Genética / Genotipo / Metabolismo / Mutación Límite: Adulto / Anciano / Aged80 / Femenino / Humanos / Masculino País/Región como asunto: Asia Idioma: Chino Revista: Chinese Journal of Experimental and Clinical Virology Año: 2012 Tipo del documento: Artículo