Expression of Glutamate Receptors in the Medial Vestibular Nuclei following Acute Hypotension
Journal of the Korean Balance Society
;
: 29-35, 2007.
Artículo
en Coreano
| WPRIM
| ID: wpr-30513
ABSTRACT
Acute hypotension induced excitation of electrical activities and expression of c-Fos protein and pERK in the vestibular nuclei. In this study, to investigate the excitatory signaling pathway in the vestibular nuclei following acute hypotension, expression of NR2A and NR2B subunits of glutamate NMDA receptor and GluR1 subunit of glutamate AMPA receptor was determined by RT-PCR and Western blotting in the medial vestibular nucleus 30 min after acute hypotension in rats. Acute hypotension increased expression of NR2A, NR2B, and pGluR1 in the medial vestibular nuclei. These results suggest that both of NMDA and AMPA glutamate receptors take part in transmission of excitatory afferent signals following acute hypotension.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Núcleos Vestibulares
/
Western Blotting
/
N-Metilaspartato
/
Receptores de Glutamato
/
Receptores AMPA
/
Ácido alfa-Amino-3-hidroxi-5-metil-4-isoxazol Propiónico
/
Ácido Glutámico
/
Hipotensión
Límite:
Animales
Idioma:
Coreano
Revista:
Journal of the Korean Balance Society
Año:
2007
Tipo del documento:
Artículo
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