Progression and direction of humanized antibody research / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 1-5, 2004.
Artículo
en Chino
| WPRIM
| ID: wpr-305239
ABSTRACT
After its advent, monoclonal antibody has gone an uneven way to its present wide applications in clinical practices, during which the humanized antibody set an important milestone accompanying a series of technique renovations, such as PCR technique, phage display and transgenic animals. Humanized antibody has developed from chimeric antibody and reshaped antibody to the present fully human antibody. Humanization of murine antibodies has been the future direction of therapeutic antibodies and this can be reflected from the fact that humanized antibodies or even human antibodies have made up majority of the therapeutic antibodies both in clinical test and in the market. The present techniques have enabled the production of fully human antibodies and given chances to the arising of antibody derivatives. They not only overcome the deficiency in application of murine antibody with different strategies, but also provide more weapons for human therapeutics. However, modifications of monoclonal antibody aiming at clinical applications need more research work in the mechanisms of antibody effector system, as well as comprehensive understanding in regulation of human immune system.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Ingeniería de Proteínas
/
Usos Terapéuticos
/
Anticuerpos
/
Anticuerpos Monoclonales
Límite:
Animales
/
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Biotechnology
Año:
2004
Tipo del documento:
Artículo
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