The Effect of Intrathecal Fentanyl on Hypnotic Requirement of Propofol during Spinal Anesthesia / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 496-501, 2005.
Artículo
en Coreano
| WPRIM
| ID: wpr-30524
ABSTRACT
BACKGROUND:
Intrathecal opioid, a useful adjunct to prolong analgesic effects, potentiates spinal anesthesia. The present study was designed to evaluate the effect of intrathecal fentanyl on the hypnotic requirements of propofol during spinal anesthesia.METHODS:
Sixty patients scheduled for elective urologic surgery under spinal anesthesia were randomly assigned to one of four groups. In Group 1 (n =15), spinal anesthesia was performed with hyperbaric bupivacaine 10 mg, in Group 2 (n = 15) with hyperbaric bupivacaine 10 mg plus fentanyl 10microgram, in Group 3 (n = 15) with hyperbaric bupivacaine 10 mg plus fentanyl 20microgram, and in Group 4 (n = 15) with hyperbaric bupivacaine 10 mg plus fentanyl 30microgram. After performing spinal anesthesia, the target plasma concentration of propofol was set at 2.0microgram/ml. Effect site concentration (Ce) was measured when the BIS's reached 80 or 70. Ce was titrated to maintain a BIS of 70-80. Observer's sedation scoring (OAA/S), systolic and diastolic pressures, SpO2 and total infusion dose were measured every 10 minutes for 1 hour.RESULTS:
Ce's at a BIS of 80 were 1.2+/-0.3microgram/ml (Group 1), 1.0+/-0.3microgram/ml (Group 2), 0.9+/-0.2microgram/ml (Group 3), and 0.8+/-0.2microgram/ml (Group 4), respectively. Ce's at a BIS of 70 were 1.6+/-0.2microgram/ml (Group 1), 1.5+/-0.4microgram/ml (Group 2), 1.2+/-0.3microgram/ml (Group 3), and 1.2+/-0.3microgram/ml (Group 4), respectively. Ce's of Group 3 and Group 4 at BISs of 70 and 80 were significantly lower than those of Group 1 (P<0.05), and the propofol requirements of Groups 3 and 4 to maintain a BIS of 70-80 were significantly less than those of Group 1 (P<0.05).CONCLUSIONS:
These results indicate that adding more than 20microgram of fentanyl to hyperbaric bupivacaine for spinal anesthesia reduces the hypnotic requirement of propofol.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Plasma
/
Bupivacaína
/
Propofol
/
Fentanilo
/
Anestesia Raquidea
Límite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Anesthesiology
Año:
2005
Tipo del documento:
Artículo
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