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MUC5AC expression up-regulation goblet cell hyperplasia in the airway of patients with chronic obstructive pulmonary disease / 中国医学科学杂志(英文版)
Chinese Medical Sciences Journal ; (4): 181-184, 2005.
Artículo en Inglés | WPRIM | ID: wpr-305427
ABSTRACT
<p><b>OBJECTIVE</b>To determine the number of goblet cells, the change of MUC5AC expression in chronic obstructive pulmonary disease (COPD) patients and the relationship of smoking with goblet cell, MUC5AC, and lung function.</p><p><b>METHODS</b>Eighteen patients undergoing lung resections for a solitary peripheral carcinoma were classified by lung function as having COPD. Twenty patients with normal lung function served as the control group. Normal lobe bronchioles far away from the lesion site were taken for paraffin section. Goblet cells were identified by AB/PAS staining and the expression of MUC5AC in the paraffin's section was tested by immunohistochemistry.</p><p><b>RESULTS</b>Goblet cell hyperplasia was observed in the COPD group. The positive rate of goblet cell in COPD group (0.20% +/- 0.10%) was significantly higher than that in the normal lung function group (0.13% +/- 0.06%, P < 0.05). The positive rate of MUC5AC expression in the COPD group (0.27% +/- 0.09%) was higher than that in the normal lung function group (0.20% +/- 0.10%, P < 0.05). The positive rate of goblet cell in smokers (27.93% +/- 9.00%) of the COPD group and normal lung function group was higher than that in non-smokers (17.70% +/- 9.37%, P < 0.05), while MUC5AC expression had no significant difference between smokers and non-smokers (17.88% +/- 6.44% and 10.88% +/- 7.10%, respectively).</p><p><b>CONCLUSION</b>For COPD patients with declined lung function, there were goblet cell hyperplasia and increased expression of MUC5AC. MUC5AC expression up-regulation may due to goblet cell hyperplasia. Smoking may be an important factor for goblet cell hyperplasia.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Patología / Bronquios / Fumar / Regulación hacia Arriba / Células Caliciformes / Enfermedad Pulmonar Obstructiva Crónica / Proliferación Celular / Epitelio / Glándulas Exocrinas / Mucina 5AC Tipo de estudio: Estudio pronóstico Límite: Anciano / Humanos Idioma: Inglés Revista: Chinese Medical Sciences Journal Año: 2005 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Patología / Bronquios / Fumar / Regulación hacia Arriba / Células Caliciformes / Enfermedad Pulmonar Obstructiva Crónica / Proliferación Celular / Epitelio / Glándulas Exocrinas / Mucina 5AC Tipo de estudio: Estudio pronóstico Límite: Anciano / Humanos Idioma: Inglés Revista: Chinese Medical Sciences Journal Año: 2005 Tipo del documento: Artículo