Regulatory effect of GDNF on the proliferation and differentiation of mammalian spermatogonial stem cells / 中华男科学杂志
National Journal of Andrology
;
(12): 628-633, 2011.
Artículo
en Chino
| WPRIM
| ID: wpr-305830
ABSTRACT
The glial cell-derived neurotrophic factor (GDNF) is a member of the transforming growth factor beta (Tgf-beta) superfamily, which is produced by Sertoli cells and plays an important role in the proliferation and differentiation of spermatogonial stem cells (SSC). The addition of proper amount of GDNF to the culture media can promote SSC proliferation in vitro. Besides, GDNF regulates the self-renewal and differentiation of SSCs through various signaling pathways. This review focuses on the effects of GDNF on the proliferation and differentiation of mammalian SSCs and GDNF-mediated signaling pathways.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Espermatogonias
/
Células Madre
/
Transducción de Señal
/
Diferenciación Celular
/
Biología Celular
/
Proliferación Celular
/
Factor Neurotrófico Derivado de la Línea Celular Glial
/
Mamíferos
/
Metabolismo
Límite:
Animales
Idioma:
Chino
Revista:
National Journal of Andrology
Año:
2011
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS