Effect of interleukin-8 in cell invasion and proliferation of human breast cancer / 中华外科杂志
Chinese Journal of Surgery
;
(12): 1541-1544, 2005.
Artículo
en Chino
| WPRIM
| ID: wpr-306072
ABSTRACT
<p><b>OBJECTIVE</b>To identify the effect of interleukin-8 in cell progression and invasion of human breast cancer.</p><p><b>METHODS</b>Human cytokine antibody arrays were applied to screen a panel of cytokine expression from 11 human breast cancer cell lines, and the mechanism of identified key factors involved in breast cancer progression was studied.</p><p><b>RESULTS</b>Profiling of cytokine expression showed the expression of interleukin-8 was related to estrogen receptor status, metastasis and vimentin status in the 11 human breast cancer cell lines. Elevated expression of interleukin-8 in breast cancer cells had positive correlation with breast cancer invasion. Neutralization of antibody against interleukin-8 specifically blocked interleukin-8-mediated cell invasion. However, anti-interleukin-8 antibody did not influence the proliferation of breast cancer cells.</p><p><b>CONCLUSION</b>Interleukin-8 may be the key factor involved in human breast cancer progression and invasion, and play an important role in cell invasion of breast cancer.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Fisiología
/
Neoplasias de la Mama
/
Ensayo de Inmunoadsorción Enzimática
/
Inmunohistoquímica
/
Células Tumorales Cultivadas
/
Receptores de Estrógenos
/
Interleucina-8
/
Proteína p53 Supresora de Tumor
/
Análisis por Matrices de Proteínas
Tipo de estudio:
Estudio pronóstico
Límite:
Femenino
/
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Surgery
Año:
2005
Tipo del documento:
Artículo
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