Your browser doesn't support javascript.
loading
Clinical investigation on the effect of intravesical instillation of antifibrinolytic agents with bacillus Calmette-Guerin on preventing bladder cancer recurrence / 中华外科杂志
Chinese Journal of Surgery ; (12): 1457-1460, 2005.
Artículo en Chino | WPRIM | ID: wpr-306087
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of intravesical instillation of antifibrinolytic agents with bacillus Calmette-Guerin (BCG) on preventing recurrence of superficial bladder transitional cell carcinoma (BTCC) after surgical management.</p><p><b>METHODS</b>A total of 326 cases of superficial BTCC undergoing transurethral resection of bladder tumor (TURBT) or partial cystectomy were divided into 5 groups. Then the different dosage BCG with or without antifibrinolytic agents was regular instilled into bladders (once a week, then once a month after 6 times). Group A including 66 cases received intravesical instillation of 100-120 mg BCG plus 100 mg para-aminomethyl benzoic acid (PAMBA). Group B including 64 cases instillation of 50-60 mg BCG plus 100 mg PAMBA; Group C including 65 cases 100-120 mg BCG plus 2.0 g epsilon-aminocaproic acid (EACA); Group D including 64 cases 50-60 mg BCG plus 2.0 g EACA; Group E (control group) including 67 cases 100-120 mg BCG. All the cases had been followed up for 4 to 69 months (mean, 28.5 months). Not only was cystoscopy performed every 3 months, but also biopsy was carried out to identify recurrence when necessary. Side effect was recorded after instillation.</p><p><b>RESULTS</b>The rate of tumor recurrence of Group A, Group B, Group C and Group D was 12%, 10%, 9%, 9% respectively, which was significantly lower than that of Group E (30%) (chi(2) = 5.699, 6.818, 7.380, 7.867, P = 0.017, 0.009, 0.007, 0.005). And there was no significant difference of tumor recurrence rate between Group A and Group B or between Group C and Group D (Group A and Group C high dosage BCG plus antifibrinolytic agents, while Group B and Group D low dosage BCG plus antifibrinolytic agents) (P > 0.05). But the side effects developing in Group B and Group D after BCG instillation were less than those in Group A and Group C.</p><p><b>CONCLUSIONS</b>The efficacy of BCG on prevention the recurrence of superficial BTCC can be enhanced when combined with antifibrinolytic agents. Even if the dosage of BCG was reduced by half, the efficacy didn't changed. A new approach of low dosage BCG plus antifibrinolytic agents is recommended in the prophylaxis of recurrence of bladder cancer.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Cirugía General / Neoplasias de la Vejiga Urinaria / Administración Intravesical / Vacuna BCG / Carcinoma de Células Transicionales / Adyuvantes Inmunológicos / Ácido 4-Aminobenzoico / Estudios de Seguimiento / Terapia Combinada / Usos Terapéuticos Tipo de estudio: Estudio observacional / Estudio pronóstico Límite: Adulto / Anciano / Aged80 / Femenino / Humanos / Masculino Idioma: Chino Revista: Chinese Journal of Surgery Año: 2005 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Cirugía General / Neoplasias de la Vejiga Urinaria / Administración Intravesical / Vacuna BCG / Carcinoma de Células Transicionales / Adyuvantes Inmunológicos / Ácido 4-Aminobenzoico / Estudios de Seguimiento / Terapia Combinada / Usos Terapéuticos Tipo de estudio: Estudio observacional / Estudio pronóstico Límite: Adulto / Anciano / Aged80 / Femenino / Humanos / Masculino Idioma: Chino Revista: Chinese Journal of Surgery Año: 2005 Tipo del documento: Artículo