Expression of urea transporters in sweat gland tissue of normal subjects and uremic patients / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To explore the expression of urea transporters (UTs) in the skin and sweat glands of normal subjects and patients with uremia.</p><p><b>METHODS</b>Abdominal skin biopsy samples of patients with uremia and normal patients and apocrine sweat gland tissue from patients with bromidrosis were examined for the expression of UTs using immunohistochemistry and fluorescence immunoassay for quantitative analysis.</p><p><b>RESULTS</b>Both UT-A1 and UT-B1 proteins were expressed in the skin basal cell layer, eccrine sweat gland and apocrine sweat gland tissues. In uremic patients, N-UT-A1 and UT-B1 expressions were significantly higher than those in the control (P<0.05) but C-UT-A1 expression was similar (P>0.05).</p><p><b>CONCLUSION</b>UTs are expressed in human skin basal cell layer, eccrine sweat gland and apocrine sweat gland tissues, and their expressions are upregulated in uremic patients.</p>