A Case of Severe Chronic Active Epstein-Barr Virus Infection with Aplastic Anemia and Hepatitis / 대한소화기학회지
The Korean Journal of Gastroenterology
;
: 39-43, 2016.
Artículo
en Coreano
| WPRIM
| ID: wpr-30651
ABSTRACT
Epstein-Barr virus (EBV) causes various acute and chronic diseases. Chronic active EBV infection (CAEBV) is characterized by infectious mononucleosis-like symptoms that persist for more than 6 months with high viral loads in peripheral blood and/or an unusual pattern of anti-EBV antibodies. Severe CAEBV is associated with poor prognosis with severe symptoms, an extremely high EBV-related antibody titer, and hematologic complications that often include hemophagocytic lymphohistiocytosis. However, CAEBV which led to the development of aplastic anemia (AA) has not been reported yet. A 73-year-old woman was admitted to our hospital with intermittent fever, general weakness and elevated liver enzymes. In the serologic test, EBV-related antibody titer was elevated, and real-time quantitative-PCR in peripheral blood showed viral loads exceeding 10(4) copies/microg DNA. Liver biopsy showed characteristic histopathological changes of EBV hepatitis and in situ hybridization with EBV-encoded RNA-1 was positive for EBV. Pancytopenia was detected in peripheral blood, and the bone marrow aspiration biopsy showed hypocellularity with replacement by adipocytes. AA progressed and the patient was treated with prednisolone but deceased 8 months after the diagnosis due to multiple organ failure and opportunistic infection. Herein, we report a rare case of severe CAEBV in an adult patient accompanied by AA and persistent hepatitis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Infecciones Urinarias
/
Índice de Severidad de la Enfermedad
/
ADN Viral
/
Carbapenémicos
/
Enfermedad Crónica
/
Herpesvirus Humano 4
/
Infecciones por Virus de Epstein-Barr
/
Reacción en Cadena en Tiempo Real de la Polimerasa
/
Hepatitis
/
Anemia Aplásica
Tipo de estudio:
Estudio pronóstico
Límite:
Anciano
/
Femenino
/
Humanos
Idioma:
Coreano
Revista:
The Korean Journal of Gastroenterology
Año:
2016
Tipo del documento:
Artículo
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