Effect of mailuoning on C-Fos protein expression in rats with cerebral infarction / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 831-834, 2004.
Artículo
en Chino
| WPRIM
| ID: wpr-306772
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the protective effect of mailuoning (MLN) on nerve cells after cerebral infarction induced by photochemistry.</p><p><b>METHODS</b>Eighty SD rats were divided into three groups, the control group (n = 20), the model group (n = 30) and the MLN group (n = 30). Focal cerebro-ischemia induced by photothrombosis in adult rat was used as a model. Changes of C-Fos protein expression before and after MLN treatment were observed using immunohistochemistry, computerized imaging technique and transmission electron microscopy (TEM).</p><p><b>RESULTS</b>C-Fos positive cells located in the transitional zone between the necrotic core and normal cortex. C-Fos protein expression began to show 3 hrs after cerebral infarction, peaked at 6 hrs. As compared with the model group, C-Fos expression was significantly reduced in the MLN group (P<0.01).</p><p><b>CONCLUSION</b>MLN could markedly reduce the injury of nerve cell in the transitional zone, the protection may be related with its inhibition on C-Fos protein expression.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Fotoquímica
/
Medicamentos Herbarios Chinos
/
Infarto Cerebral
/
Proteínas Proto-Oncogénicas c-fos
/
Ratas Sprague-Dawley
/
Fármacos Neuroprotectores
/
Genética
/
Metabolismo
Límite:
Animales
Idioma:
Chino
Revista:
Chinese Journal of Integrated Traditional and Western Medicine
Año:
2004
Tipo del documento:
Artículo
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