Investigation of myocardial stunning after cardiopulmonary resuscitation in pigs / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 155-162, 2011.
Artículo
en Inglés
| WPRIM
| ID: wpr-306877
ABSTRACT
<p><b>OBJECTIVE</b>To investigate cardiac function and myocardial perfusion during 48 h after cardiopulmonary resuscitation (CPR), further to test myocardial stunning and seek indicators for long-term survival after CPR.</p><p><b>METHODS</b>After 4 min of untreated ventricular fibrillation, fifteen anesthetized pigs were studied at baseline and 2 h, 4 h, 24 h, and 48 h after restoration of spontaneous circulation (ROSC). Hemodynamic data, echocardiography and gated-single photon emission computed tomography myocardial perfusion images were carried out.</p><p><b>RESULTS</b>Mean arterial pressure (MAP), coronary perfusion pressure (CPP) and cardiac troponin I (CTNI) showed significant differences between eventual survival animals and non-survival animals at 4 h after ROSC (109.2 ± 10.7 mmHg vs. 94.8 ± 12.3 mmHg, P=0.048; 100.8 ± 6.9 mmHg vs. 84.4±12.6 mmHg, P=0.011; 1.60 ± 0.13 ug/L vs. 1.75 ± 0.10 ug/L, P=0.046). Mitral valve early-to-late diastolic peak velocity ratio, mitral valve deceleration time recovered 24 h; ejection faction and the summed rest score recovered 48 h after ROSC.</p><p><b>CONCLUSION</b>Cardiac systolic and early active relaxation dysfunctions were reversible within survival animals; cardiac stunning might be potentially adaptive and protective after CPR. The recovery of MAP, CPP, and CTNI could be the indicators for long-term survival after CPR.</p>
Texto completo:
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Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fisiología
/
Porcinos
/
Factores de Tiempo
/
Fibrilación Ventricular
/
Presión Sanguínea
/
Reanimación Cardiopulmonar
/
Aturdimiento Miocárdico
/
Circulación Coronaria
/
Paro Cardíaco
/
Hemodinámica
Límite:
Animales
Idioma:
Inglés
Revista:
Biomedical and Environmental Sciences
Año:
2011
Tipo del documento:
Artículo
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