Expression of CD4(+) and IL-17, Foxp3 in non-small cell lung cancer and their correlation with microvessel density / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 596-599, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-307335
ABSTRACT
<p><b>OBJECTIVE</b>To explore the expression of CD4(+), IL-17 and Foxp3 in non-small cell lung cancer (NSCLC) and their relationship with microvessel density (MVD).</p><p><b>METHODS</b>The expressions of CD4(+), IL-17, Foxp3, CD31 and CD34 in the cancer tissues of 102 NSCLC cases were detected by immunohistochemisty. The relationship among the expressions of CD4(+), IL-17, Foxp3 and MVD was analyzed. The count data were analyzed using χ(2) test. The measurement data were analyzed using single-factor analysis of variance, and significance level α = 0.05.</p><p><b>RESULTS</b>Among the factors affecting CD31 expression, there was a statistically significant difference between the strong positive Foxp3 expression (++) and negative (-) and positive expressions (+) in the NSCLC cancer tissues (P < 0.05), and between the expressions in stage I and III cancer tissues (P < 0.05). Among the factors affecting CD34 expression, there was a significant difference between positive IL-7 expression (+) and strong positive IL-7 expression (++) (P < 0.05), between negative Foxp3 expression (-) and strong positive Foxp3 expression (++) (P < 0.05), and between the CD34 expressions in stage I and III and between those in stage II and III NSCLC cancer tissues (P < 0.05).</p><p><b>CONCLUSIONS</b>CD4, IL-17and Foxp3 may be involved in the tumor suppression caused by host immune response, and are related with the NSCLC invasion and metastasis.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Antígenos CD4
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Carcinoma de Pulmón de Células no Pequeñas
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Antígenos CD34
/
Molécula-1 de Adhesión Celular Endotelial de Plaqueta
/
Interleucina-17
/
Factores de Transcripción Forkhead
/
Microvasos
/
Neoplasias Pulmonares
/
Metabolismo
Límite:
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Oncology
Año:
2012
Tipo del documento:
Artículo
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