Studies on bioassay-guided anti-inflammatory fraction in bark of Albizia julibrissin combined determination with LC-MS-MS / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2021-2025, 2007.
Artículo
en Chino
| WPRIM
| ID: wpr-307539
ABSTRACT
<p><b>OBJECTIVE</b>To search the anti-inflammatory fraction of Albizia julibrissin.</p><p><b>METHOD</b>Inflammatory model of Kunming mice ear edema induced by croton oil and determination combined with the LC-MS-MS-guided fractionation and isolation were used.</p><p><b>RESULT</b>The n-butanol fraction (AJ-B) obtained from the ethanolic extract of the Cortex albiziae was the major active fraction. The lignan glycosides fraction (AJ-B-1), which was further isolated from AJ-B, showed significant anti-inflammatory activity and exhibited dose-dependent relationship in the dose of 5 to 20 mg x kg(-1).</p><p><b>CONCLUSION</b>The method of bioassay-guided fractionation and isolation combined with the LC-MS-MS determination may be of benefit to the logical studies on the bioactive fractions or constituents of traditional Chinese materia medica.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Plantas Medicinales
/
Bioensayo
/
Aceite de Crotón
/
Medicamentos Herbarios Chinos
/
Química
/
Antiinflamatorios no Esteroideos
/
Cromatografía Líquida de Alta Presión
/
Lignanos
/
Corteza de la Planta
/
Albizzia
Límite:
Animales
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2007
Tipo del documento:
Artículo
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