Diterpenoid alkaloids from roots of Aconitum recemulosum and their inhibitory effects on PAF-induced platelet aggregation / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1935-1937, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-307671
ABSTRACT
<p><b>OBJECTIVE</b>To study diterpenoid alkaloids from the roots of Aconitum recemulosum, and their inhibitory effects on PAF-induced platelet aggregation.</p><p><b>METHOD</b>The root of A. recemulosum was extracted with 95% EtOH. The total alkaloids extracted were isolated and purified by several kinds of column chromatography over silica gel, RP-18, and Sephadex LH-20, and identified based on spectral analysis. And the inhibitory effects of isolated compounds on PAF-induced platelet aggregation were detected.</p><p><b>RESULT</b>Five alkaloids were isolated and identified as sachaconitine (1), 14-acetylsachaconitine (2), hemsleyanine C (3), circinasine A (4), and talatisamine (5). The results showed compounds 1 and 2 have moderate inhibition effect on PAF.</p><p><b>CONCLUSION</b>Compounds 1-5 were firstly isolated from this plant. Furthermore, compounds 1 and 2 possessed moderate inhibitory effects on PAF-induced platelet aggregation.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Coagulantes
/
Extractos Vegetales
/
Química
/
Agregación Plaquetaria
/
Raíces de Plantas
/
Aconitum
/
Diterpenos
/
Alcaloides
Límite:
Humanos
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2009
Tipo del documento:
Artículo
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