Effect of glucocorticoid treatment on the clinical outcome of patients with early-stage liver failure / 南方医科大学学报
Journal of Southern Medical University
;
(12): 554-556, 2011.
Artículo
en Chino
| WPRIM
| ID: wpr-307887
ABSTRACT
<p><b>OBJECTIVE</b>To assess the therapeutic effect and safety of short-term low-dose glucocorticoid in the treatment of early-stage subacute liver failure.</p><p><b>METHODS</b>Eight-seven patients with early-stage HBV-related subacute liver failure were randomized into glucocorticoid treatment group (n=43) and control group (n=44). The patients in the control group received lamivudine and routine integrated treatment), and those in the treatment group were given additional short-term low-dose glucocorticoid treatment. The endpoint measurements included the survival rate, mean hospital stay and adverse reactions to the treatments.</p><p><b>RESULTS</b>The patients receiving glucocorticoid treatment exhibited significantly greater improvement of the liver functions than those in the control group (P<0.05). The rate of successful treatment was significantly higher in treatment group with shortened hospital stay (P<0.05), but the virological response rate and incidence of complications showed no significant differences between the two groups (P>0.05).</p><p><b>CONCLUSION</b>The short-term low-dose glucocorticoid treatment can improve survival rate and shorten the mean hospital stay of patients with HBV-related early-stage subacute liver failure patients. Glucocorticoid treatment is relatively safe when administered with strictly controlled indications and time window for intervention.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Resultado del Tratamiento
/
Fallo Hepático
/
Lamivudine
/
Hepatitis B Crónica
/
Usos Terapéuticos
/
Quimioterapia
/
Glucocorticoides
Tipo de estudio:
Ensayo Clínico Controlado
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Journal of Southern Medical University
Año:
2011
Tipo del documento:
Artículo
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