The advances in research on phosphorylation of polyglutamine disease / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 414-417, 2008.
Artículo
en Chino
| WPRIM
| ID: wpr-308051
ABSTRACT
Polyglutamine (polyQ) diseases are a group of hereditary neurodegenerative disorders caused by expansion of a glutamine repeat in responsible gene products. To date, the pathogenesis of polyQ diseases is still not very clear, but many researches suggest that phosphorylation of mutant proteins plays a critical role on the process of Huntington's disease, dentatorubral-pallidoluysian atrophy, spinal bulbar muscular atrophy, spinocerebellar ataxia1 and spinocerebellar ataxia 3/Machado-Joseph disease.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Péptidos
/
Fosforilación
/
Fisiología
/
Atrofia Muscular Espinal
/
Degeneraciones Espinocerebelosas
/
Enfermedad de Huntington
/
Enfermedad de Machado-Joseph
/
Repeticiones de Trinucleótidos
/
Expansión de Repetición de Trinucleótido
/
Trastornos Heredodegenerativos del Sistema Nervioso
Límite:
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Medical Genetics
Año:
2008
Tipo del documento:
Artículo
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