Long-term prognostic analysis of thymectomized patients with myasthenia gravis / 中华医学杂志(英文版)

ABSTRACT

<p><b>OBJECTIVE</b>To study the factors affecting the long-term prognosis of patients with myasthenia gravis (MG) after thymectomy.</p><p><b>METHODS</b>170 MG patients who had undergone thymectomies were studied retrospectively. Among them, 124 patients received long-term follow-up for more than 40 months postoperatively. The COX regression analysis model was used to analyze the factors that may influence the long-term prognosis. These factors included thymus pathology, patient gender, age, duration of disease at the time of surgery, preoperative Osserman classification and medication.</p><p><b>RESULTS</b>The research showed that thymus pathology was the single independent factor that affected the postoperative long-term prognosis. The long-term survival rates differed significantly with thymus pathological types: hyperplasia > benign thymoma > atrophy > malignant thymoma (P < 0.05).</p><p><b>CONCLUSION</b>The different pathological types of the thymus were the important factor affecting long-term survival in MG patients after thymectomy.</p>