Effect of injection of testosterone undecanoate and depot medroxyprogesterone acetate on the suppression of spermatogenesis / 中华男科学杂志
National Journal of Andrology
;
(12): 572-581, 2004.
Artículo
en Chino
| WPRIM
| ID: wpr-308298
ABSTRACT
<p><b>OBJECTIVE</b>To observe depot medroxyprogesterone acetate (DMPA) and testosterone undecanoate (TU) injected at 8-week intervals for the suppression of spermatogenesis in healthy Chinese men.</p><p><b>METHODS</b>After screening, 30 healthy volunteers were enrolled and randomly assigned to 3 dosage-groups (n = 10/group) 1000 mg TU (Group A), 1000 mg TU plus 150 mg DMPA (Group B), 1000 mg TU plus 300 mg DMPA (Group C). All dosages were given as intramuscular injections at 8-week intervals. The study consisted of an 8-week control (baseline) period, a 24-week treatment period and a 24-week recovery period.</p><p><b>RESULTS</b>Consistent azoospermia or severe oligozoospermia was achieved and maintained in all the volunteers during the treatment period, except 2 in the mere TU group who experienced a "rebound" in sperm concentrations. An 8-week regimen of TU plus DMPA at both tested combination dosages effectively suppressed spermatogenesis to azoospermia. All volunteers tolerated the injections; no serious adverse effects were reported.</p><p><b>CONCLUSION</b>The lower combined dosage is recommended for further testing in an expanded clinical trial or contraceptive efficacy study.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Recuento de Espermatozoides
/
Espermatogénesis
/
Testosterona
/
China
/
Estudios Prospectivos
/
Hormona Liberadora de Gonadotropina
/
Acetato de Medroxiprogesterona
/
Sistema Hipotálamo-Hipofisario
/
Andrógenos
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudio observacional
Límite:
Adulto
/
Humanos
/
Masculino
País/Región como asunto:
Asia
Idioma:
Chino
Revista:
National Journal of Andrology
Año:
2004
Tipo del documento:
Artículo
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