Effect and mechanism of alpha1-adrenoceptor blocker combined with antibiotics for chronic prostatitis / 中华男科学杂志
National Journal of Andrology
;
(12): 518-520, 2004.
Artículo
en Chino
| WPRIM
| ID: wpr-308309
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect and mechanism of alpha1-adrenoceptor blocker combined with antibiotics in the treatment of chronic prostatitis.</p><p><b>METHODS</b>Eighty patients with chronic prostatitis were divided into two groups, one treated with alpha1-adrenoceptor blocker (Terazosin 2 mg qn) and Levo-ofloxacin (0.2 bid), and the other given Levo-ofloxacin (0.2 bid) alone for 6 weeks. Chronic prostatitis symptom index (CPSI), urodynamic data and prostatic secretion examination were compared before and after treatment.</p><p><b>RESULTS</b>The CPSI score of the treated group decreased from 31.8 +/- 7.4 to 15.5 +/-6.6, while that of the control group decreased from 30.9 +/- 7.1 to 21.4 +/- 6.2. There was significant difference between the two groups (P < 0.05). The maximum flow rates before and after the combined treatment were 16.5 +/- 6.3 ml/s and 20.4 +/- 4.6 ml/s, while those before and after Levo-ofloxacin administration were 16.1 +/-5.8 ml/s and 17.3 +/- 6.8 ml/s. The difference was significant (P < 0.05). The maximum urethral pressure of the combined treatment group decreased from 92.5 +/- 15.3 cm H2O to 72.5 +/- 13.4 cm H2O, while that of the control group decreased from 93.2 +/- 14.8 cm H2O to 91.7 +/- 13.6 cm H2O.</p><p><b>CONCLUSION</b>Alpha1-adrenoceptor blocker can lower the intraurethral pressure, which prevents urine from refluxing to the prostate. Alpha1-adrenoceptor blocker combined with antibiotics is effective for chronic prostatitis.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Prostatitis
/
Urodinámica
/
Enfermedad Crónica
/
Antagonistas Adrenérgicos alfa
/
Quimioterapia
/
Quimioterapia Combinada
/
Antagonistas de Receptores Adrenérgicos alfa 1
/
Antibacterianos
Límite:
Adulto
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
National Journal of Andrology
Año:
2004
Tipo del documento:
Artículo
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