Effects of quercetin on morphology and VEGF secretion of leukemia cells NB4 in vitro / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 25-27, 2006.
Artículo
en Chino
| WPRIM
| ID: wpr-308430
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of quercetin on cell morphology and VEGF expression of acute myeloblastic leukemia cells NB4 in vitro.</p><p><b>METHODS</b>The cytomorphology of NB4 cells was assessed by Wright-stain, apoptosis rate by apoptotic marker Annexin V, and VEGF secretion level by ELISA.</p><p><b>RESULTS</b>Typical apoptosis was found in NB4 cells after treatment with quercetin. Apoptotic marker Annexin V analysis showed that the apoptotic rate of NB4 cells was increased after treatment with quercetin. The secretion of VEGF of NB4 cells was significantly decreased after treatment with quercetin.</p><p><b>CONCLUSION</b>Quercetin can induce apoptosis and inhibit secretion of VEGF in NB4 leukemia cells.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Farmacología
/
Quercetina
/
Leucemia Mieloide Aguda
/
Apoptosis
/
Secreciones Corporales
/
Línea Celular Tumoral
/
Factor A de Crecimiento Endotelial Vascular
/
Metabolismo
/
Antineoplásicos Fitogénicos
Límite:
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Oncology
Año:
2006
Tipo del documento:
Artículo
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