Evaluation of transdermal property in vitro of different breviscapine lipid carrier gels / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 3554-3557, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-308579
ABSTRACT
<p><b>OBJECTIVE</b>To prepare four breviscapine lipid carrier gels and general gel, and to study the transdermal promotive effects of them in vitro.</p><p><b>METHOD</b>Improved Franz-type diffusion cell and isolated rat skin were used as transdermal barrier, and the transdermal property was fitted by pharmacokinetics equations. The unit area cumulative permeation quantity of breviscapine was determined by HPLC method.</p><p><b>RESULT</b>The 24 hours' unit area cumulative permeation quantity of SLN gel was the highest, followed in descending order were transfersomal gel, liposomal gel, NLC gel and general gel. The transdermal property in vitro of SLN gel fitted in with Higuchi pharmacokinetics equation.</p><p><b>CONCLUSION</b>The lipid carrier gels had different transdermal promotive effects to breviscapine, SLN gel was the best one as breviscapine transdermal carrier.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Absorción Cutánea
/
Flavonoides
/
Administración Cutánea
/
Portadores de Fármacos
/
Farmacocinética
/
Química
/
Química Farmacéutica
/
Sistemas de Liberación de Medicamentos
/
Lípidos
/
Métodos
Límite:
Animales
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2012
Tipo del documento:
Artículo
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