Late endothelial function in children with coronary aneurysm due to Kawasaki disease / 中国当代儿科杂志

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate the late endothelial function in children with coronary aneurysm due to Kawasaki disease (KD).</p><p><b>METHODS</b>Thirty-one children with coronary aneurysms due to KD who had the disease course for more than 1 year and twenty-one age-matched healthy children were enrolled. Brachial artery endothelium-dependent and -independent flow-mediated dilation (FMD), carotid arterial stiffness index (SI) and intima-media thickness (IMT) were measured by high-frequency ultrasound.</p><p><b>RESULTS</b>There were 9 cases of medium and 22 cases of giant coronary aneurysms in the KD group. Twelve KD patients had evidence of myocardial ischemia. Compared to the normal controls, the endothelium-dependent FMD decreased (P<0.05), the carotid arterial SI increased (P<0.05), and the carotid arterial intima-media thickness increased significantly (P<0.05) in children with coronary aneurysms due to KD. The endothelium-dependent FMD decreased more significantly in 12 KD patients with myocardial ischemia than in those without any evidence of myocardial ischemia (P<0.05).</p><p><b>CONCLUSIONS</b>Late endothelial dysfunction exists in children with coronary aneurysms due to KD, especially in those with myocardial ischemia.</p>