Significance of soluble DLL1 in diagnosis of intracranial infectious diseases in children / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 205-207, 2011.
Article
en Zh
| WPRIM
| ID: wpr-308833
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the significance of soluble DLL1 (Delta-like-1) levels of cerebrospinal fluid (CSF) and serum in the diagnosis of intracranial infection in children.</p><p><b>METHODS</b>Fifty children with intracranial infection, including 20 cases of tuberculous meningitis (TM), 20 cases of viral meningitis (VM) and 10 cases of purulent meningitis (PM), and 20 children without intracranial infection (control group) were enrolled. The levels of soluble DLL1 in CSF and serum were measured using ELISA.</p><p><b>RESULTS</b>The level of CSF soluble DLL1 in the TM group was significantly higher than that in the VM, PM and control groups (2.89 ± 1.72 ng/mL vs 0.14 ± 0.14 ng/mL, 0.27 ± 0.21 ng/mL, 0.13 ± 0.12 ng/mL; P<0.01). The level of serum soluble DLL1 in the TM group was also significantly higher than that in the VM, PM and control groups (12.61 ± 6.45 ng/mL vs 2.28 ± 2.27 ng/mL, 2.38 ± 1.79 ng/mL, 2.26 ± 2.10 ng/mL; P<0.01). The levels of soluble DLL1 in the CSF and serum in the VM and PM groups were not significantly different from those in the control group.</p><p><b>CONCLUSIONS</b>Soluble DLL1 as a novel indicator might have potentially important value in the diagnosis of TM.</p>
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Supuración
/
Tuberculosis Meníngea
/
Sangre
/
Líquido Cefalorraquídeo
/
Meningitis Bacterianas
/
Péptidos y Proteínas de Señalización Intercelular
/
Diagnóstico
/
Proteínas de la Membrana
/
Meningitis Viral
Tipo de estudio:
Diagnostic_studies
Límite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Idioma:
Zh
Revista:
Chinese Journal of Contemporary Pediatrics
Año:
2011
Tipo del documento:
Article