Health-Related Quality of Life in Children with Biliary Atresia Living with Native Livers
Annals of the Academy of Medicine, Singapore
; : 61-68, 2016.
Article
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| WPRIM
| ID: wpr-309457
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WPRO
ABSTRACT
<p><b>INTRODUCTION</b>This study aimed to quantify and investigate factors affecting the health-related quality of life (HRQoL) in children with biliary atresia (BA) living with their native livers.</p><p><b>MATERIALS AND METHODS</b>A cross-sectional study on the HRQoL using the PedsQL4.0 generic core scales in children with BA aged between 2 to 18 years followed up at the University Malaya Medical Centre (UMMC) in Malaysia was conducted. Two groups, consisting of healthy children and children with chronic liver disease (CLD) caused by other aetiologies, were recruited as controls.</p><p><b>RESULTS</b>Children with BA living with their native livers (n = 36; median (range) age: 7.4 (2 to 18) years; overall HRQoL score: 85.6) have a comparable HRQoL score with healthy children (n = 81; median age: 7.0 years; overall HQRoL score: 87.4; P = 0.504) as well as children with CLD (n = 44; median age: 4.3 years; overall score: 87.1; P = 0.563). The HRQoL of children with BA was not adversely affected by having 1 or more hospitalisations in the preceding 12 months, the presence of portal hypertension, older age at corrective surgery (>60 days), a lower level of serum albumin (≤34 g/L) or a higher blood international normalised ratio (INR) (≥1.2). Children who had liver transplantation for BA did not have a significantly better HRQoL as compared to those who had survived with their native livers (85.4 vs 85.7, P = 0.960).</p><p><b>CONCLUSION</b>HRQoL in children with BA living with their native livers is comparable to healthy children.</p>
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Índice:
WPRIM
Asunto principal:
Psicología
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Calidad de Vida
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Cirugía General
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Atresia Biliar
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Albúmina Sérica
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Estudios de Casos y Controles
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Estado de Salud
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Enfermedad Crónica
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Estudios Transversales
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Factores de Edad
Tipo de estudio:
Observational_studies
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Prevalence_studies
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Risk_factors_studies
Límite:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
Annals of the Academy of Medicine, Singapore
Año:
2016
Tipo del documento:
Article