Lung adenoma development and NK activity in mice treated with multiple carcinogens
Journal of Korean Medical Science
;
: 1-5, 1992.
Artículo
en Inglés
| WPRIM
| ID: wpr-30961
ABSTRACT
A wide-spectrum initiation model was investigated in mice. Sequential treatments with diethylnitrosamine, urethane and N-methylnitrosourea, with or without a promoter, phenobarbital, resulted in tumor formation in the lungs in 85-90% of animals, but did not produce any tumorous lesions in other organs. The lung tumors were adenomas and the mean number of adenomas was 2.2-2.6 per mouse. Phenobarbital combination had no additive effect on lung tumor incidence and multiplicity. Splenic NK cell activity showed inconsistent increment in the carcinogen plus phenobarbital-treated group during the experiment (P less than 0.05).
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fenobarbital
/
Uretano
/
Células Asesinas Naturales
/
Distribución Aleatoria
/
Adenoma
/
Dietilnitrosamina
/
Neoplasias Pulmonares
/
Metilnitrosourea
Límite:
Animales
Idioma:
Inglés
Revista:
Journal of Korean Medical Science
Año:
1992
Tipo del documento:
Artículo
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