Nitric oxide synthetase and carbon monoxide decrease in the penile corpus cavernous of hyper homocysteine rats / 中华男科学杂志
National Journal of Andrology
;
(12): 701-703, 2008.
Artículo
en Chino
| WPRIM
| ID: wpr-309811
ABSTRACT
<p><b>OBJECTIVE</b>To detect the levels of nitric oxide synthetase (NOS) and carbon monoxide (CO) in the penile corpus cavernous of adult male Wistar rats with high homocysteine (Hhcy) and to explore the relationship of NOS and CO levels with erectile dysfunction.</p><p><b>METHODS</b>Twenty Wistar rats were equally and randomly divided into a control and an Hhcy group and fed on normal diet and normal diet with 3.0% methionine respectively. Four weeks later, the levels of NOS and CO in the penile corpus cavernous were detected by ultraviolet spectrophotometry and that of serum homocysteine by the cycle enzyme method.</p><p><b>RESULTS</b>Compared with the control group, the levels of NOS and CO in the penile corpus cavernous were significantly lower in the Hhcy group, (6.45 +/- 1.12) nmol/(g x min) vs (10.77 +/- 0.60) nmol/(g x min) and (10.60 +/- 0.92) micromol/L vs (13.36 +/- 0.44) micromol/L, while that of homocysteine was significantly higher, (22.32 +/- 1.65) micromol/L) vs (4.90 +/- 1.73) micromol/L.</p><p><b>CONCLUSION</b>Four-week diet with methionine can cause Hhcy and significantly decreased levels of NOS and CO in the penile corpus cavernous in Wistar rats. Hhcy is an independent risk factor of erectile dysfunction.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pene
/
Espectrofotometría Ultravioleta
/
Sangre
/
Monóxido de Carbono
/
Ratas Wistar
/
Óxido Nítrico Sintasa
/
Hiperhomocisteinemia
/
Homocisteína
/
Metabolismo
Tipo de estudio:
Factores de riesgo
Límite:
Animales
Idioma:
Chino
Revista:
National Journal of Andrology
Año:
2008
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS