Meta-analysis on peginterferon plus ribavirin in treatment of hepatitis C virus genotype 1 or 4 infection in HIV patients / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 315-319, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-310348
ABSTRACT
<p><b>OBJECTIVE</b>To perform a Meta-analysis on peginterferon with interferon in treatment of HIV patients coinfected with refractory genotype HCV.</p><p><b>METHODS</b>A literature search of Medline was conducted to identify eligible randomized controlled trials. Meta analysis was conducted to evaluate peginterferon and interferon in treatment of coinfected HCV genotype 1 or 4 in HIV patients.</p><p><b>RESULT</b>Six trials of 88 matched the selection criteria. Total 1,131 patients with coinfection of HCV genotype 1 or 4 and HIV were included. Sustain viral response was higher in patients treated with peginterferon plus ribavirin compared with that of interferon plus ribavirin (26 % compared with 8 %) or peginterferon alone (26 % compared with 13 %). Severe adverse effects and withdrawal rates were similar for patients treated with peginterferon and patients treated with interferon.</p><p><b>CONCLUSION</b>Peginterferon plus ribavirin in treatment of patients with coinfection of genotype 1 or 4 HCV and HIV can achieve higher sustain viral response and the likelihoods of serious adverse effects and withdrawal rates are similar to other therapies.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Antivirales
/
Polietilenglicoles
/
Ribavirina
/
Virología
/
Proteínas Recombinantes
/
Infecciones por VIH
/
Ensayos Clínicos Controlados Aleatorios como Asunto
/
Clasificación
/
Interferón-alfa
/
Hepacivirus
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudio pronóstico
/
Revisiones Sistemáticas Evaluadas
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Journal of Zhejiang University. Medical sciences
Año:
2009
Tipo del documento:
Artículo
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