Clinical analysis of 10 cases of olfactory neuroblastoma / 浙江大学学报·医学版

ABSTRACT

<p><b>OBJECTIVE</b>To review the diagnosis, treatment and prognosis of olfactory neuroblastoma.</p><p><b>METHODS</b>Clinical data were retrospectively reviewed in 10 cases of olfactory neuroblastoma admitted from 1998 to 2002, including data of transmission electron microscopic (TEM) observation in 4 cases. According to Kadish's classification, 2 cases were in stage A, 4 in stage B and 4 in stage C. Three patients were treated with surgery alone, 7 with combined surgery and radiation.</p><p><b>RESULT</b>Among 10 cases, the overall 5-year survival rate was 60 %(6/10); 3 patients died from local recurrence, 1 lost follow-up. TEM demonstrated granules in the cytoplasm of 3 patients.</p><p><b>CONCLUSION</b>The combined surgery and radiation can achieve excellent local control. Transmission electron microscope is important for its diagnosis.</p>