Relationship between XRCC1 polymorphisms and susceptibility to prostate cancer in men from Han, Southern China / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
; (6): 331-338, 2007.
Article
en En
| WPRIM
| ID: wpr-310506
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>AIM</b>To investigate the association among XRCC1 polymorphisms, smoking, drinking and the risk of prostate cancer (PCa) in men from Han, Southern China.</p><p><b>METHODS</b>In a case-control study of 207 patients with PCa and 235 cancer-free controls, frequency-matched by age, we genotyped three XRCC1 polymorphisms (codons 194, 280 and 399) using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RELP) method.</p><p><b>RESULTS</b>Among the three polymorphisms, we found that the XRCC1 Arg399Gln variant allele was associated with increased PCa risk (adjusted odd ratio [OR]: 1.67, 95% confident interval [CI]: 1.11-2.51), but the XRCC1 Arg194Trp variant allele had a 38% reduction in risk of PCa (adjusted OR: 0.62, 95% CI: 0.41-0.93). However, there was no significant risk of PCa associated with Arg280His polymorphism. When we evaluated the three polymorphisms together, we found that the individuals with 194Arg/Arg wild-type genotype, Arg280His and Arg399Gln variant genotypes had a significantly higher risk of PCa (adjusted OR: 4.31; 95% CI: 1.24-14.99) than those with three wild-type genotypes. In addition, we found that Arg399Gln variant genotypes had a significant risk of PCa among heavy smokers (adjusted OR: 2.04; 95% CI: 1.03-4.05).</p><p><b>CONCLUSION</b>These results suggest that polymorphisms of XRCC1 appear to influence the risk of PCa and may modify risks attributable to environmental exposure.</p>
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Índice:
WPRIM
Asunto principal:
Neoplasias de la Próstata
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Sangre
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Polimorfismo de Longitud del Fragmento de Restricción
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Adenocarcinoma
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Oportunidad Relativa
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Estudios Seroepidemiológicos
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China
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Epidemiología
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Factores de Riesgo
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Predisposición Genética a la Enfermedad
Tipo de estudio:
Etiology_studies
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Observational_studies
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Risk_factors_studies
Límite:
Aged
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Humans
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Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
Asian Journal of Andrology
Año:
2007
Tipo del documento:
Article