Arrhythmia triggered by stretching rabbit left ventricles and the block effect of streptomysin / 中国应用生理学杂志

ABSTRACT

<p><b>AIM</b>To observe the effect of stretching left ventricles in the end of action potential on rabbit cardiac activity, and to investigate its possible mechanisms.</p><p><b>METHODS</b>Stretch (120 mmHg, 50 ms) was applied in the end of action potential by the pressure-clamp technique to observe if there would be any changes in rabbit cardiac activity and streptomycin (500 micromol/L) was used to identify the mechanism.</p><p><b>RESULTS</b>Stretch in the end of action potential caused arrhythmia (P < 0.05) and streptomycin blocked the above effect (P < 0.05).</p><p><b>CONCLUSION</b>Streptomycin could block the effect of stretching left ventricles in the end of action potential on rabbit cardiac activity, which indicates that stretch-activated ion channels involve it.</p>