Anti-arthritic and anti-oxidative effect of ethyl acetate fraction of Blumea balsamlfera residues in rat adjuvant-induced arthritis / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 3819-3823, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-310982
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of ethyl acetate fraction of Blumea balsamifera (BBE) residue on treating rats of adjuvant arthritis (AA) and its mechanism.</p><p><b>METHOD</b>The rats were immunized with the Freund's complete adjuvant (FCA). After modeling, 28 days' treatment with BBE was performed. During the experimental process, rat mass, toe girth, arthritic index (AI), proliferation of immune organs and pathological section were measured. After treatment, blood samples were collected through fossa orbitalis vein for detection of serum SOD, MDA, GSH, NO, OH*, ALP, AST, ALT, NAG and SA content using colorimetric method and IL-1, IL-6, TNF-α content using ELISA method.</p><p><b>RESULT</b>Administration with BBE (high dose) could significantly ameliorate joint swelling and arthritis index, effectively inhibit synovial hyperplasia, down-regulate the levels of MDA, NO, OH*, ALP, AST, ALT, NAG, SA, IL-1, IL-6, TNF-α and up-regulate the SOD and GSH levels in serum.</p><p><b>CONCLUSION</b>The results suggested BBE possesses substantial anti-arthritis and antioxidant activities.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Artritis Experimental
/
Sangre
/
Medicamentos Herbarios Chinos
/
Química
/
Antiinflamatorios no Esteroideos
/
Interleucina-6
/
Interleucina-1
/
Factor de Necrosis Tumoral alfa
/
Ratas Sprague-Dawley
/
Estrés Oxidativo
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2014
Tipo del documento:
Artículo
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