DNA Methylation and Birth Weight: a Genome-wide Analysis / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 667-670, 2017.
Artículo
en Inglés
| WPRIM
| ID: wpr-311364
ABSTRACT
The study illustrate the inner correlation between global DNA methylation variation and different birth weights. Infant birth weight was used to identify cases and controls. Cord blood and placentas were collected. We performed DNA methylation profiling of bisulphite-converted DNA. We have identified many differentially methylated CpG sites in experimental groups; these sites involved in hundreds of signalings. Among these, more than ten pathways were referred to the glucose and lipid metabolism. Methylation changes in the insulin-signaling pathway (ISP), adipocytokine signaling pathway (ASP) and MAPK signaling pathway are involved in the fetal programming of diabetes..
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Tamaño de los Órganos
/
Fisiología
/
Placenta
/
Peso al Nacer
/
Transducción de Señal
/
Regulación del Desarrollo de la Expresión Génica
/
Metilación de ADN
/
Estudio de Asociación del Genoma Completo
Límite:
Femenino
/
Humanos
/
Masculino
/
Recién Nacido
/
Embarazo
Idioma:
Inglés
Revista:
Biomedical and Environmental Sciences
Año:
2017
Tipo del documento:
Artículo
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