Inhibitory effect of melatonin on morphine withdrawal syndromes and the content of NO in plasma and brain tissue in morphine dependent mice / 药学学报
Acta Pharmaceutica Sinica
;
(12): 175-177, 2002.
Artículo
en Chino
| WPRIM
| ID: wpr-312018
ABSTRACT
<p><b>AIM</b>To observe the effect of melatonin (MT) on morphine withdrawal syndromes and determine the content of NO in plasma and brain tissue in morphine dependent mice.</p><p><b>METHODS</b>A physical dependent model in mice was established by subcutaneous injection of morphine. MT (15 mg.kg-1, qd x 3) was given by intragastric infusion (ig) for three days. Withdrawal syndromes were induced by intraperitoneal injection of naloxon (5 mg.kg-1). The intensity of withdrawal syndromes was evaluated according to the jumping latency, the jumping times and the body weight loss. The content of NO was detected with Griess method.</p><p><b>RESULTS</b>The jumping latency of morphine withdrawal reaction was prolonged and the jumping times were reduced obviously by ig MT. The increased NO content in plasma and brain tissue in morphine dependent mice was reduced by ig MT.</p><p><b>CONCLUSION</b>The physical withdrawal syndromes and the content of NO in plasma and brain tissue in morphine dependent mice are inhibited by MT.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Síndrome de Abstinencia a Sustancias
/
Sangre
/
Encéfalo
/
Usos Terapéuticos
/
Modelos Animales de Enfermedad
/
Melatonina
/
Metabolismo
/
Dependencia de Morfina
/
Óxido Nítrico
Límite:
Animales
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2002
Tipo del documento:
Artículo
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