Effects of recombinant bovine basic fibroblast growth factor on osteoblast's growth and c-fos expression / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 8-11, 2004.
Artículo
en Chino
| WPRIM
| ID: wpr-312878
ABSTRACT
Rat's osteoblasts cultured in vitro were stimulated by recombinant bovine basic fibroblast growth factor(rb-bFGF). After 1-2 days, the osteoblast grew long protuberance, the numbers of osteoblasts were greater than the control groups', the vitality of osteoblasts was better than that of control groups. After 1 hour, the expression of c-fos in osteoblast increased when compared with that in the control group. After the osteoblasts having been stimulated for 1-2 days, the expression of c-fos increased more conspicuously. These results show that bFGF can boost the osteoblast to grow and proliferate and can enhance the expression of c-fos gene. The increase of c-fos gene's expression may be an important step in the signal transformation process of all kinds of stimulation boosting osteoblast to proliferate.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Osteoblastos
/
Farmacología
/
Proteínas Recombinantes
/
Células Cultivadas
/
Regulación de la Expresión Génica
/
Factor 2 de Crecimiento de Fibroblastos
/
Proteínas Proto-Oncogénicas c-fos
/
Genes fos
/
Ratas Wistar
/
Biología Celular
Límite:
Animales
Idioma:
Chino
Revista:
Journal of Biomedical Engineering
Año:
2004
Tipo del documento:
Artículo
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