Effect of ru'ai shuhou recipe on immune response in HER2/neu tranagenic mice undergoing breast cancer carcinogenesis process / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 717-756, 2010.
Artículo
en Chino
| WPRIM
| ID: wpr-313214
ABSTRACT
<p><b>OBJECTIVE</b>To explore the immune response induced by HER2/neu oncogene in the breast cancer (BC) carcinogenesis process and the immunological mechanism of Ru'ai Shuhou Recipe (RSR) in the prevention and treatment of BC.</p><p><b>METHODS</b>HER2/neu transgenic spontaneous breast tumor model mice were fed with RSR from 5 weeks old, the occurrence of breast tumor in them was observed, and the changes of T cell-mediated immune response and associated cytokines were detected during the carcinogenesis process, i. e., when mice aged between 15 and 25 weeks.</p><p><b>RESULTS</b>RSR showed significant effects in postponing and reducing the carcinogenesis of primary breast tumor, up-regulating the amount of T cell in splenic lymphocyte in tumor-bearing mice, promoting the proliferation of T lymphocyte, and inducing the secretion of cytokines such as interleukin-2, interleukin-12 and interferon-y.</p><p><b>CONCLUSIONS</b>A serial immune response reveals in the carcinogenesis process. The immunologic function of HER-2/neu transgenic mice is significantly different to that of the same strain non-transgenic mice. Effect of RSR in preventing and postponing breast cancer carcinogenesis is possibly realized through enhancing the anti-tumor immune response of transgenic mice themselves.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Bazo
/
Neoplasias de la Mama
/
Medicamentos Herbarios Chinos
/
Ratones Transgénicos
/
Linfocitos T
/
Receptor ErbB-2
/
Genes erbB-2
/
Biología Celular
/
Proliferación Celular
Límite:
Animales
Idioma:
Chino
Revista:
Chinese Journal of Integrated Traditional and Western Medicine
Año:
2010
Tipo del documento:
Artículo
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