Beta-Sitosterol in the Treatment of Benign Prostatic Obstruction (A 3 Month Open Uncontrolled Symptomatic Assessment) / 대한비뇨기과학회지

ABSTRACT

In a prospective open uncontrolled study, Beta-Sitosterol( cholesterol lowering agent) was investigated in the treatment of benign prostatic obstruction, Forty patients were included in the study. All patients were treated with 60mg of Beta-Sitosterol daily for 3months. Mean maximum and average flow rates were increased significantly. Volume of residual urines were reduced from an initial 52ml to 30ml in the final weeks(p <0.001). The mean intervals of diuria were increased from an initial 1.7 hour to 2.6hour and the frequencies of nocturia were reduced from an initial 2.1times to 1.8times in the final weeks(p<0.001), Other obstructive symptom were subjectively improved. Side effects were minimal. It was concluded that the Beta-Sitosterol at a dose of 20mg tid is a safe and effective therapeutic alternative in patients with benign prostatic obstruction and may be used in patients awaiting surgery and those who unfit for operation.