Association analysis between single-nucleotide polymorphisms in the FCER1A gene and serum total IgE level in patients with allergic rhinitis / 中华耳鼻咽喉头颈外科杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate whether the single nucleotide polymorphisms (SNP) in the FCER1A gene are associated with serum total IgE level in Chinese allergic rhinitis (AR) cohort.</p><p><b>METHODS</b>A total of 378 patients diagnosed as AR was included in this study. Serum total IgE level was detected by UniCAP100 testing system. A total of 8 representativeness marker SNP which were in FCER1A gene region were selected according to the Beijing people database from Hapmap website and the running results of Haploview 4.1 software. The individual genotyping was performed by MassARRAY platform.</p><p><b>RESULTS</b>Three hundred and seventy-eight individuals (227 males and 151 females) with AR were prospectively recruited. The median of the total serum IgE measurements for the study population were 150 kU/L and ranged from 6.94 kU/L to 5000 kU/L. Levene tests showed the homogeneity of variance of total IgE level among different genotypes regarding each SNP locus. ANOVA tests demonstrated that none of the selected polymorphism loci in FCER1A was associated with total IgE level.</p><p><b>CONCLUSION</b>Present study failed to find an association between SNP in the FCER1A gene region and serum total IgE level in Chinese AR.</p>