Expression of T-bet and its regulation on CD4(+) T cell polarization in aplastic anemia / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 546-549, 2011.
Article
en Zh
| WPRIM
| ID: wpr-313948
Biblioteca responsable:
WPRO
ABSTRACT
Aplastic anemia (AA) is an autoimmune disease which take hematopoietic tissue as target cells. T lymphocyte-mediated cellular immune abnormality plays a key role in the pathogenesis of AA. Increase and hyperfunction of Thl lymphocytes are main feature of AA disease. The recent studies indicated that T-bet is Th1 cell-specific transcription factor, is crucial factor for polarization of CD4(+) T lymphocytes to Th1. High expression of T-bet in AA patients is an important link in pathogenesis of AA. In this article, T-bet and its relation with AA, including expression of T-bet in AA patients, the regulation of T-bet on polarization of CD4(+) T lymphocytes are reviewed.
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Sangre
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Linfocitos T CD4-Positivos
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Células TH1
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Recuento de Linfocitos
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Proteínas de Dominio T Box
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Alergia e Inmunología
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Anemia Aplásica
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Metabolismo
Límite:
Humans
Idioma:
Zh
Revista:
Journal of Experimental Hematology
Año:
2011
Tipo del documento:
Article