Effects of total flavone of Abelmoschl Manihot L. Medic on the function of platelets and its mechanism / 中国结合医学杂志
Chinese journal of integrative medicine
;
(12): 57-59, 2005.
Artículo
en Inglés
| WPRIM
| ID: wpr-314148
ABSTRACT
<p><b>OBJECTIVE</b>To study the effects of total flavone of Abelmoschl Manihot L. Medic (TFA) on the function of platelets and to explore its mechanism.</p><p><b>METHODS</b>Rat models of artery-veins bypassing thrombus formation were used. The platelets of rabbits were collected. Platelet aggregation was induced by collagen and intracellular calcium ion concentration ([Ca(2+)]i) was assayed by Fura-2 method.</p><p><b>RESULTS</b>TFA (25, 50, 100 mg/kg) significantly and dose-dependently reduced the weight of thrombus. TFA (0.025, 0.05, 0.1 mg/ml) possessed dose-dependant inhibitory effects on rabbits' platelet aggregation induced by collagen. TFA significantly reduced the resting and CaCl(2)-induced increase of free intracellular calcium concentration ([Ca(2+)]i) in rabbit platelet in vitro.</p><p><b>CONCLUSION</b>TFA has an antiplatelet effect via the inhibition on the influx of Ca(2+).</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Concentración Osmolar
/
Farmacología
/
Pruebas de Función Plaquetaria
/
Sangre
/
Plaquetas
/
Cloruro de Calcio
/
Medicamentos Herbarios Chinos
/
Inhibidores de Agregación Plaquetaria
/
Bloqueadores de los Canales de Calcio
/
Trombosis de las Arterias Carótidas
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Inglés
Revista:
Chinese journal of integrative medicine
Año:
2005
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS