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Expression and significance of Ang1, Ang2 and receptor Tie2 in hemangioma / 中华整形外科杂志
Chinese Journal of Plastic Surgery ; (6): 515-518, 2007.
Artículo en Chino | WPRIM | ID: wpr-314179
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship of angiogenesis and the Ang family members/ receptor (Ang/Tie2) in hemangioma.</p><p><b>METHODS</b>Expression of Ang1, Ang2 and the receptor Tie2 was detected with immunohistochemical SP method and RT-PCR method in 17 cases of proliferating hemangioma, 13 involuting cases and 10 cases of normal children skin.</p><p><b>RESULTS</b>The expression of Ang2 and Tie2 was higher markedly in proliferating hemangiomas than in involuting hemangiomas (P < 0.01), and was rare or negative in normal skin. Expression of Ang1 was rare or negative both in hemangioma and normal skin without significant difference between them (P > 0.05).</p><p><b>CONCLUSION</b>Ang/Tie2 system may play an important role in the proliferating and involuting process of hemangioma.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Patología / Receptor TIE-2 / Angiopoyetina 1 / Angiopoyetina 2 / Hemangioma / Metabolismo Límite: Child, preschool / Humanos / Lactante Idioma: Chino Revista: Chinese Journal of Plastic Surgery Año: 2007 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Patología / Receptor TIE-2 / Angiopoyetina 1 / Angiopoyetina 2 / Hemangioma / Metabolismo Límite: Child, preschool / Humanos / Lactante Idioma: Chino Revista: Chinese Journal of Plastic Surgery Año: 2007 Tipo del documento: Artículo