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Non-T-cell depleted HLA haploidentical peripheral blood stem cell transplantation for hematological malignancies: report of 36 cases / 中华血液学杂志
Chinese Journal of Hematology ; (12): 82-86, 2009.
Artículo en Chino | WPRIM | ID: wpr-314531
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the clinical outcome of human leukocyte antigen (HLA) haploidentical peripheral blood stem cell transplantation (PBSCT) from related donors for hematological malignancies.</p><p><b>METHODS</b>Thirty-six patients with hematological malignancies, with a median age of 25 (11-48) years, were transplanted with PBSC from an HLA-haploidentical family donors 7 were 1 locus mismatched and 29 were 2-3 loci mismatched. The recipients received myeloablative conditioning regimen, in combination with different immunosuppressants according to the degree of HLA disparity followed by non-T-cell depleted PBSCT. The median number of CD34+ cells were 11 (4.16-21.00) x 10(6)/kg.</p><p><b>RESULTS</b>All patients achieved sustained, full donor-type engraftment. Fifteen patients (41.7%) developed grade I-II aGVHD. Among 29 patients followed up more than 18 months, 17 (58.6%) developed cGVHD. There was no statistical difference in decrease and recovery of T, B and NK cell subsets after transplantation between HLA haploidentical group and HLA identical PBSCT group. The median follow-up duration was 15 (4 -69) months. Five patients (13.9% ) relapsed. The 2-year probability of leukemia-free survival (LFS) was 82.2%.</p><p><b>CONCLUSION</b>Non-T-cell depleted HLA-haploidentical PBSCT is safe and feasible for patients with hematological malignancies after myeloablative conditioning regimen combined with intensive immunosuppressants.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Terapéutica / Trasplante Homólogo / Estudios de Seguimiento / Resultado del Tratamiento / Neoplasias Hematológicas / Acondicionamiento Pretrasplante / Trasplante de Células Madre de Sangre Periférica / Alergia e Inmunología / Genética / Enfermedad Injerto contra Huésped Tipo de estudio: Estudio observacional / Estudio pronóstico Límite: Adolescente / Adulto / Niño / Femenino / Humanos / Masculino Idioma: Chino Revista: Chinese Journal of Hematology Año: 2009 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Terapéutica / Trasplante Homólogo / Estudios de Seguimiento / Resultado del Tratamiento / Neoplasias Hematológicas / Acondicionamiento Pretrasplante / Trasplante de Células Madre de Sangre Periférica / Alergia e Inmunología / Genética / Enfermedad Injerto contra Huésped Tipo de estudio: Estudio observacional / Estudio pronóstico Límite: Adolescente / Adulto / Niño / Femenino / Humanos / Masculino Idioma: Chino Revista: Chinese Journal of Hematology Año: 2009 Tipo del documento: Artículo