Study of radiation synovectomy using (188)Re-Sulfide in hemophilic arthritis / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 151-152, 2002.
Artículo
en Chino
| WPRIM
| ID: wpr-314663
ABSTRACT
<p><b>OBJECTIVE</b>To study the effectiveness of radiation synovectomy with (188)Re-sulfide.</p><p><b>METHODS</b>Twenty rabbit models of joint synovitis were injected intra-articularly with different doses of (188)Re-sulfide from 7.4 to 37.0 MBq. By pathological examination, the effects of (188)Re-sulfide on synovium and cartilage were evaluated. Clinically, 10 joints of 7 cases of hemophilic arthritis with (188)Re-sulfide radiation synovectomy were performed. MRI was taken before and after the synovectomy to evaluate the treatment effects.</p><p><b>RESULTS</b>In rabbit models, when (188)Re-sulfide dose larger than 14.8 MBq, the radiation effect on synovitis was remarkable, including thinning the thickened synovium and reducing the inflammatory cells. When radio-activity dose increased to 37.0 MBq, pathological damage was noted in cartilage. Clinical trial demonstrated that radiation synovectomy by (188)Re-sulfide could reduce the frequencies of intra-articular hemorrhage. MRI showed that edema and villi reduced.</p><p><b>CONCLUSIONS</b>Radiation synovectomy using (188)Re-sulfide is effective on synovitis in hemophilic arthritis.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Efectos de la Radiación
/
Radioterapia
/
Renio
/
Sulfuros
/
Membrana Sinovial
/
Sinovitis
/
Radioisótopos de Rutenio
/
Cloruros
/
Estudios de Seguimiento
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
Límite:
Animales
/
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Hematology
Año:
2002
Tipo del documento:
Artículo
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